Article

Integrative Epigenomic Landscape of Alzheimer’s Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with Tau

2025-02-17

Abstract excerpt

Alzheimer’s disease (AD) brains are characterized by neuropathologic and biochemical changes that are highly variable across individuals. Capturing epigenetic factors that associate with this variability can reveal novel biological insights into AD pathophysiology. We conducted an epigenome-wide association study of DNA methylation (DNAm) in 472 AD brains with neuropathologic measures (Braak stage, Thal phase, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6f792bc-38ed-5ac5-baa9-bc8f06554ecf
DOI: 10.1101/2025.02.12.637140

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Epigenomic Landscape of Alzheimer’s Disease Brains Reveals Oligodendrocyte Molecular Perturbations Associated with TauDOI 10.1101/2025.02.12.637140Read

Early oligodendrocyte dysfunction signature in Alzheimer’s disease: Insights from DNA methylomics and transcriptomicsSemantic proximity Read

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-typesSemantic proximity Read

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals <i>OTUD4</i> in shared dysregulated signatures across pathological subtypesSemantic proximity Read

Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer’s DiseaseSemantic proximity Read

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brainSemantic proximity Read

Integrated Whole Transcriptome and DNA Methylation Analysis Identifies Gene Networks Specific to Late-Onset Alzheimer's DiseaseSemantic proximity Read

Epigenomics of Alzheimer's disease.Semantic proximity Read

Epigenomic subtypes of late-onset Alzheimer’s disease reveal distinct microglial signaturesSemantic proximity Read

Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease.Semantic proximity Read

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's diseaseSemantic proximity Read

Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneitySemantic proximity Read