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Article

Alzheimer's loci: epigenetic associations and interaction with genetic factors

24 Apr 2015

Abstract excerpt

OBJECTIVE: We explore the role of DNA methylation in Alzheimer's disease (AD). To elucidate where DNA methylation falls along the causal pathway linking risk factors to disease, we examine causal models to assess its role in the pathology of AD. METHODS: DNA methylation profiles were generated in 740 brain samples using the Illumina HumanMet450K beadset. We focused our analysis on CpG sites from 11 AD...

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PMID: 26125039
DOI: 10.1002/acn3.201

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