Article

Early microglial priming in Alzheimer’s disease revealed by ME-seq

2026-02-02

Abstract excerpt

Epigenetic modifications, particularly DNA methylation, change dynamically with aging and are implicated in Alzheimer’s Disease (AD), yet how methylation interfaces with transcriptional and chromatin regulation at single-cell resolution remains poorly understood. Progress has been limited by a lack of scalable technologies capable of jointly profiling these regulatory layers. Here, we present ME-seq, a highly scal...

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Literature Corpus work: db9dde8f-d308-5d3a-8685-1148acb7832a
DOI: 10.64898/2026.01.30.702946

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