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Article

Linking DNA methylation in brain regions to Alzheimer's disease risk: a Mendelian randomization study.

Human molecular genetics - 4 Jun 2025

Zhong Hua, Zhu Jingjing, Liu Shuai, Zhou Dan, Long Quan, Wu Chong, Zhao Bingxin, Cheng Chao, Yang Yaohua, Wu Qing, Wu Yong, Li Changwei, Wang Zhaoming, Wu Jianyong, Guo Xingyi, Zhi Degui, Deng Youping, Wu Lang

Abstract excerpt

AIM: DNA methylation in brain regions represents a potential mechanism linking genetic variation to Alzheimer's disease (ad) risk, yet most studies have focused on blood-derived methylation markers. In this study, we conducted a systematic Mendelian randomization (MR) study to evaluate associations between predicted brain region-specific DNA methylation levels and ad risk, using methylation quantitative trait...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40267236
DOI: 10.1093/hmg/ddaf053
PMCID: PMC13377460

Genes

PCGF3
RITA1

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