Article

Widespread methylation quantitative trait loci and their role in schizophrenia risk

2020-09-24

Abstract excerpt

DNA methylation (DNAm) regulates gene expression and may represent gene-environment interactions. Using whole genome bisulfite sequencing, we surveyed DNAm in a large sample (n=344) of human brain tissues. We identify widespread genetic influence on local methylation levels throughout the genome, with 76% of SNPs and 38% of CpGs being part of methylation quantitative trait loci (meQTLs). These associations can fur...

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Literature Corpus work: 5a385b80-6f71-59fe-bfcd-54dbb3a061f8
DOI: 10.1101/2020.09.24.311878

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