Article

Genome-wide QTL mapping across three tissues highlights several Alzheimer’s and Parkinson’s disease loci potentially acting via DNA methylation

2023-12-24

Abstract excerpt

DNA methylation (DNAm) is an epigenetic mark with essential roles in disease development and predisposition. Here, we created genome-wide maps of methylation quantitative trait loci (meQTL) in three peripheral tissues and used Mendelian randomization (MR) analyses to assess the potential causal relationships between DNAm and risk for two common neurodegenerative disorders, i.e. Alzheimer’s disease (AD) and Parkins...

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Literature Corpus work: 56b02b79-56e6-5004-8a80-552bbf8872b9
DOI: 10.1101/2023.12.22.23300365

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