Article

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19

2021-09-02

Abstract excerpt

Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host immune system. We and others have shown that host genetic variation influences the development of illness requiring critical care 1 or hospitalisation 2;3;4 following SARS-Co-V2 infection. The GenOMICC (Genetics of Mortality in Critical Care) study recruits critically-ill cases and compares their genomes with population contro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 488a362e-3e25-50f0-9c9c-87114be34904
DOI: 10.1101/2021.09.02.21262965

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequencing identifies multiple loci for critical illness caused by COVID-19DOI 10.1101/2021.09.02.21262965Read

Whole-genome sequencing reveals host factors underlying critical COVID-19Semantic proximity Read

GWAS and meta-analysis identifies multiple new genetic mechanisms underlying severe Covid-19Semantic proximity Read

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.Semantic proximity Read

Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis.Semantic proximity Read

Genetic mechanisms of critical illness in Covid-19Semantic proximity Read

Common and rare variant analyses combined with single-cell multiomics reveal cell-type-specific molecular mechanisms of COVID-19 severitySemantic proximity Read

Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity.Semantic proximity Read

Whole genome sequence meta-analyses reveal common and rare genetic associations with critical COVID-19Semantic proximity Read

Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common VariantsSemantic proximity Read

Host genome analysis of structural variations by Optical Genome Mapping provides clinically valuable insights into genes implicated in critical immune, viral infection, and viral replication pathways in patients with severe COVID-19Semantic proximity Read

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.Semantic proximity Read

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran ProgramSemantic proximity Read