Article
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.
PLoS genetics - 1 Apr 2022
Verma Anurag, Tsao Noah L, Thomann Lauren O, Ho Yuk-Lam, Iyengar Sudha K, Luoh Shiuh-Wen, Carr Rotonya, Crawford Dana C, Efird Jimmy T, Huffman Jennifer E, Hung Adriana, Ivey Kerry L, Levin Michael G, Lynch Julie, Natarajan Pradeep, Pyarajan Saiju, Bick Alexander G, Costa Lauren, Genovese Giulio, Hauger Richard, Madduri Ravi, Pathak Gita A, Polimanti Renato, Voight Benjamin, Vujkovic Marijana, Zekavat Seyedeh Maryam, Zhao Hongyu, Ritchie Marylyn D, Chang Kyong-Mi, Cho Kelly, Casas Juan P, Tsao Philip S, Gaziano J Michael, O'Donnell Christopher, Damrauer Scott M, Liao Katherine P
Abstract excerpt
The study aims to determine the shared genetic architecture between COVID-19 severity with existing medical conditions using electronic health record (EHR) data. We conducted a Phenome-Wide Association Study (PheWAS) of genetic variants associated with critical illness (n = 35) or hospitalization (n = 42) due to severe COVID-19 using genome-wide association summary data from the Host Genetics Initiative. PheWAS...
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