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Article

Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity.

Cell systems - 17 Aug 2022

Zhang Sai, Cooper-Knock Johnathan, Weimer Annika K, Shi Minyi, Kozhaya Lina, Unutmaz Derya, Harvey Calum, Julian Thomas H, Furini Simone, Frullanti Elisa, Fava Francesca, Renieri Alessandra, Gao Peng, Shen Xiaotao, Timpanaro Ilia Sarah, Kenna Kevin P, Baillie J Kenneth, Davis Mark M, Tsao Philip S, Snyder Michael P

Abstract excerpt

The determinants of severe COVID-19 in healthy adults are poorly understood, which limits the opportunity for early intervention. We present a multiomic analysis using machine learning to characterize the genomic basis of COVID-19 severity. We use single-cell multiome profiling of human lungs to link genetic signals to cell-type-specific functions. We discover >1,000 risk genes across 19 cell types, which account...

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Identifiers

PMID: 35690068
DOI: 10.1016/j.cels.2022.05.007
PMCID: PMC9163145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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