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Human Genomics of COVID-19 Pneumonia: Contributions of Rare and Common Variants

17 May 2023

Abstract excerpt

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of cases. We review studies of the human genetics of life-threatening COVID-19 pneumonia, focusing on both rare and common variants. Large-scale genome-wide association studies have identified more than 20 common loci robustly associated with...

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PMID: 37196358
DOI: 10.1146/annurev-biodatasci-020222-021705

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