Article

Host genome analysis of structural variations by Optical Genome Mapping provides clinically valuable insights into genes implicated in critical immune, viral infection, and viral replication pathways in patients with severe COVID-19

2021-01-08

Abstract excerpt

<h4>Background</h4> The varied clinical manifestations and outcomes in patients with SARS-CoV-2 infections implicate a role of host-genetics in the predisposition to disease severity. This is supported by evidence that is now emerging, where initial reports identify common risk factors and rare genetic variants associated with high risk for severe/ life-threatening COVID-19. Impressive global efforts have focused...

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Literature Corpus work: 175c1834-b98d-5e43-b89e-0aa82150bede
DOI: 10.1101/2021.01.05.21249190

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