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Whole-genome sequencing reveals host factors underlying critical COVID-19

7 Mar 2022

Abstract excerpt

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly...

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PMID: 35255492
DOI: 10.1038/s41586-022-04576-6

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