Article

Common and rare variant analyses combined with single-cell multiomics reveal cell-type-specific molecular mechanisms of COVID-19 severity

2021-06-21

Abstract excerpt

<h4>ABSTRACT</h4> The determinants of severe COVID-19 in non-elderly adults are poorly understood, which limits opportunities for early intervention and treatment. Here we present novel machine learning frameworks for identifying common and rare disease-associated genetic variation, which outperform conventional approaches. By integrating single-cell multiomics profiling of human lungs to link genetic signals to c...

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Literature Corpus work: b68db5e6-d4c7-51ae-89b4-6bb64281e180
DOI: 10.1101/2021.06.15.21258703

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