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Article

Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis.

Journal of medical virology - 1 Nov 2025

Chen Hongwei, Li Zan, Han Xue, Zhang Shumiao, Zhang Haoyang, Chen Yongkun, Shu Yuelong

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous genetic loci associated with COVID-19 susceptibility and severity. However, it remains unclear which variants specifically contribute to the progression from hospitalization to critical illness. To address this, we identified 394 symptom-differentiating SNPs (sdSNPs) by directly comparing GWAS summary statistics between critical and hospitalized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41268733
DOI: 10.1002/jmv.70719

Genes

FUT2
ICAM5
ICAM1
IFNA10
IZUMO1
MICB
PLSCR1
RASIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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