Article

High-throughput discovery of regulatory effector domains in human RNA-binding proteins

2024-07-19

Abstract excerpt

<h4>Summary</h4> RNA regulation plays an integral role in tuning gene expression and is controlled by thousands of RNA-binding proteins (RBPs). We develop and use a high-throughput recruitment assay (HT-RNA-Recruit) to identify regulatory domains within human RBPs by recruiting over 30,000 protein tiles from 367 RBPs to a reporter mRNA. We discover over 100 unique RNA-regulatory effectors in 86 distinct RBPs, pre...

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Literature Corpus work: aec90ae6-79bc-50da-bcf0-0c3331affd30
DOI: 10.1101/2024.07.19.604317

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