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Article

Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry

2024-10-28

Abstract excerpt

<h4>SUMMARY</h4> Understanding how human gene expression is coordinately regulated by functional units of proteins across the genome remains a major biological goal. Here, we present COMET, a high-throughput screening platform for com binatorial e ffector targeting for the identification of transcriptional modulators. We generate libraries of combinatorial dCas9-based fusion proteins, containing two to six effe...

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Identifiers and source

Literature Corpus work
66d2c241-3cbd-505c-9a64-8d9011a8e44a
DOI
10.1101/2024.10.28.620517
Open publication

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Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistryDOI 10.1101/2024.10.28.620517
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