Article

The location and development of Replicon Cluster Domains in early replicating DNA

2023-08-22

Abstract excerpt

<h4>Background: </h4> : It has been known for many years that in metazoan cells, replication origins are organised into clusters where origins within each cluster fire near-synchronously. Despite clusters being a fundamental organising principle of metazoan DNA replication, the genomic location of origin clusters has not been documented. <h4>Methods: </h4> : We synchronised human U2OS by thymidine block and relea...

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Literature Corpus work: 484069fc-d418-520f-a77f-dcabc320ff40
DOI: 10.12688/wellcomeopenres.18742.2

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