Article

The Genomic Architecture of Human DNA Replication Origins

2025-12-01

Abstract excerpt

The exact sites of DNA replication origins in human and other metazoans remain elusive. Examining human whole-genome sequencing data of 2,616 specimens, we observed conjoining reads at 2,025,756 non-random genomic positions, likely arising from nascent DNA and thus defining replication origins. These origins exhibited a 16 bp motif and periodic occurrence at the intervals of 10.5 bp and 200 bp. Genome-wide replica...

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Literature Corpus work: 57c70ff8-af80-5646-be07-d141fb1d7d6e
DOI: 10.1101/2025.11.29.691293

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