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Article

Replicating Large Genomes: Divide and Conquer.

Molecular cell - 2 Jun 2016

Rivera-Mulia Juan Carlos, Gilbert David M

Abstract excerpt

Complete duplication of large metazoan chromosomes requires thousands of potential initiation sites, only a small fraction of which are selected in each cell cycle. Assembly of the replication machinery is highly conserved and tightly regulated during the cell cycle, but the sites of initiation are highly flexible, and their temporal order of firing is regulated at the level of large-scale multi-replicon domains....

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Source

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Identifiers

PMID: 27259206
DOI: 10.1016/j.molcel.2016.05.007
PMCID: PMC4893193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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