Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells

24 Mar 2020

Abstract excerpt

BACKGROUND: DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local transcriptional potential. Here, we present RT profiles of unprecedented temporal resolution in two human embryonic stem cell lines, human colon carcinoma line HCT116,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32209126
DOI: 10.1186/s13059-020-01983-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsPMID 32209126Read ↗

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read ↗

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read ↗

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read ↗

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem CellsSemantic proximity Read ↗

Embryonic genome instability upon DNA replication timing program emergenceSemantic proximity Read ↗

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read ↗

Replication Timing Networks: a novel class of gene regulatory networksSemantic proximity Read ↗

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read ↗

Optimized Repli-seq: Improved DNA Replication Timing Analysis by Next-Generation SequencingSemantic proximity Read ↗

DNA replication timing reveals genome-wide features of transcription and fragilitySemantic proximity Read ↗

Telomere-to-telomere human DNA replication timing profilesSemantic proximity Read ↗

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.