Article

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

2016-10-29

Abstract excerpt

Expression QTL (eQTL) detection has emerged as an important tool for unravelling of the relationship between genetic risk factors and disease or clinical phenotypes. Most studies use single marker linear regression to discover primary signals, followed by sequential conditional modeling to detect secondary genetic variants affecting gene expression. However, this approach assumes that functional variants are spars...

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Literature Corpus work: 48253374-fb31-5953-8f09-8ea6b296fc42
DOI: 10.1101/084293

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