Article

Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

2023-02-14

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotype information to identify quantitative trait loci (QTL) for gene expression and splicing in...

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Literature Corpus work: 9db0043d-8c15-574b-8fa7-a74e39bf85f7
DOI: 10.1101/2023.02.09.23285622

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