Article

Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populations

2026-03-18

Abstract excerpt

Genetic variants that influence transcript abundance, called expression quantitative trait loci (eQTL), are fundamental to understanding gene regulation and disease etiology. However, eQTL studies have overlooked the influence of the ancestral origin of a gene on its regulation. We implemented a new statistical framework that maps local ancestry-specific regulatory variation, revealing pervasive ancestry-specific...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 71147390-d6a0-516a-9d2e-b425c668b03d
DOI: 10.64898/2026.03.17.26348586

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local ancestry modulates gene expression: shifting our understanding of genetic regulation and disease association within and across populationsDOI 10.64898/2026.03.17.26348586Read

Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Semantic proximity Read

Genetic Architecture of Gene Expression in European and African Americans: An eQTL Mapping Study in GENOA.Semantic proximity Read

Expression quantitative trait loci (eQTL): from population genetics to precision medicine.Semantic proximity Read

On Using Local Ancestry to Characterize the Genetic Architecture of Human Phenotypes: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations as a ModelSemantic proximity Read

Genes with differential expression across ancestries are enriched in ancestry-specific disease effects likely due to gene-by-environment interactions.Semantic proximity Read

Improved multi-ancestry fine-mapping identifies<i>cis</i>-regulatory variants underlying molecular traits and disease riskSemantic proximity Read

Powerful mapping of<i>cis</i>-genetic effects on gene expression across diverse populations reveals novel disease-critical genesSemantic proximity Read

Ancestry-specific regulatory and disease architectures are likely due to cell-type-specific gene-by-environment interactionsSemantic proximity Read

Sources of gene expression variation in a globally diverse human cohortSemantic proximity Read

Patterns of cis regulatory variation in diverse human populations.Semantic proximity Read

Effects of cis and trans genetic ancestry on gene expression in African Americans.Semantic proximity Read

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.Semantic proximity Read