Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants.

Abstract excerpt

Standard quantitative trait locus (QTL) mapping approaches consider variant effects on a single gene at a time, despite abundant evidence of allelic pleiotropy, where a single variant can affect multiple genes simultaneously. While allelic pleiotropy describes variant effects on both local and distal genes or a mixture of molecular effects on a single gene, here, we specifically investigate allelic expression...

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