Article
Integration of expression QTLs with fine mapping via SuSiE.
PLoS genetics - 1 Jan 2024
Zhang Xiangyu, Jiang Wei, Zhao Hongyu
Abstract excerpt
Genome-wide association studies (GWASs) have achieved remarkable success in associating thousands of genetic variants with complex traits. However, the presence of linkage disequilibrium (LD) makes it challenging to identify the causal variants. To address this critical gap from association to causation, many fine-mapping methods have been proposed to assign well-calibrated probabilities of causality to candidate...
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