Article

Focus on single gene effects limits discovery and interpretation of complex trait-associated variants

2025-06-06

Abstract excerpt

Standard QTL mapping approaches consider variant effects on a single gene at a time, despite abundant evidence for allelic pleiotropy, where a single variant can affect multiple genes simultaneously. While allelic pleiotropy describes variant effects on both local and distal genes or a mixture of molecular effects on a single gene, here we specifically investigate allelic expression “proxitropy”: where a single va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 667e45ed-8a55-5dda-bc5e-b1b628fd1f10
DOI: 10.1101/2025.06.06.658175

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Focus on single gene effects limits discovery and interpretation of complex trait-associated variantsDOI 10.1101/2025.06.06.658175Read

Focus on single-gene effects limits discovery and interpretation of complex-trait-associated variants.Semantic proximity Read

Building The Human Genotype-Phenotype Map to Harness Pleiotropy and Refine Disease MechanismsSemantic proximity Read

The molecular basis, genetic control and pleiotropic effects of local gene co-expression.Semantic proximity Read

The molecular basis, genetic control and pleiotropic effects of local gene co-expressionSemantic proximity Read

Trans-eQTL mapping in gene sets identifies network effects of genetic variants.Semantic proximity Read

Functional enrichments of disease variants across thousands of independent loci in eight diseasesSemantic proximity Read

<i>Trans</i> -eQTLs reveal the architecture of human gene regulatory networksSemantic proximity Read

eQTL Catalogue: a compendium of uniformly processed human gene expression and splicing QTLsSemantic proximity Read

Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants.Semantic proximity Read

Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity.Semantic proximity Read

A global overview of pleiotropy and genetic architecture in complex traitsSemantic proximity Read

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWASSemantic proximity Read