Article
Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression.
G3 (Bethesda, Md.) - 7 Aug 2017
Zeng Biao, Lloyd-Jones Luke R, Holloway Alexander, Marigorta Urko M, Metspalu Andres, Montgomery Grant W, Esko Tonu, Brigham Kenneth L, Quyyumi Arshed A, Idaghdour Youssef, Yang Jian, Visscher Peter M, Powell Joseph E, Gibson Greg
Abstract excerpt
Expression quantitative trait locus (eQTL) detection has emerged as an important tool for unraveling of the relationship between genetic risk factors and disease or clinical phenotypes. Most studies use single marker linear regression to discover primary signals, followed by sequential conditional modeling to detect secondary genetic variants affecting gene expression. However, this approach assumes that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.