Article

Uncovering context-specific genetic-regulation of gene expression from single-cell RNA-sequencing using latent-factor models

2022-12-23

Abstract excerpt

Genetic regulation of gene expression is a complex process, with genetic effects known to vary across cellular contexts such as cell types and environmental conditions. We developed SURGE, a method for unsupervised discovery of context-specific expression quantitative trait loci (eQTLs) from single-cell transcriptomic data. This allows discovery of the contexts or cell types modulating genetic regulation without p...

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Literature Corpus work: 6bd5e2ce-5b45-5d27-8ef5-24026c6b0f3d
DOI: 10.1101/2022.12.22.521678

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