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Article

Conditional transcriptome-wide association study for fine-mapping candidate causal genes.

Nature genetics - 1 Feb 2024

Liu Lu, Yan Ran, Guo Ping, Ji Jiadong, Gong Weiming, Xue Fuzhong, Yuan Zhongshang, Zhou Xiang

Abstract excerpt

Transcriptome-wide association studies (TWASs) aim to integrate genome-wide association studies with expression-mapping studies to identify genes with genetically predicted expression (GReX) associated with a complex trait. In the present report, we develop a method, GIFT (gene-based integrative fine-mapping through conditional TWAS), that performs conditional TWAS analysis by explicitly controlling for GReX of...

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PMID: 38279040
DOI: 10.1038/s41588-023-01645-y

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