Article

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts <i> JAK2 <sup>V617F</sup> </i> Human Hematopoietic Differentiation

2022-05-11

Abstract excerpt

<h4>ABSTRACT</h4> In normal somatic tissue differentiation, changes in chromatin accessibility govern priming and commitment of precursors towards cellular fates. In turn, somatic mutations can disrupt differentiation topologies leading to abnormal clonal outgrowth. However, defining the impact of somatic mutations on the epigenome in human samples is challenging due to admixed mutated and wildtype cells. To char...

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Literature Corpus work: 47ba4082-ccd5-5763-be86-662eb6bee5c7
DOI: 10.1101/2022.05.11.491515

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