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GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells.

Cell stem cell - 4 May 2023

Turkalj Sven, Jakobsen Niels Asger, Groom Angus, Metzner Marlen, Riva Simone G, Gür E Ravza, Usukhbayar Batchimeg, Salazar Mirian Angulo, Hentges Lance D, Mickute Gerda, Clark Kevin, Sopp Paul, Davies James O J, Hughes Jim R, Vyas Paresh

Abstract excerpt

Understanding clonal evolution and cancer development requires experimental approaches for characterizing the consequences of somatic mutations on gene regulation. However, no methods currently exist that efficiently link high-content chromatin accessibility with high-confidence genotyping in single cells. To address this, we developed Genotyping with the Assay for Transposase-Accessible Chromatin (GTAC),...

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PMID: 37146586
DOI: 10.1016/j.stem.2023.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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