Article

Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing

2026-04-12

Abstract excerpt

Despite the promise of single-cell transcriptomics for understanding cell states in heterogeneous populations, widely used platforms have limited ability to link transcriptional states to somatic mutations within the same cells. Here, we introduce Genotyping in Fixed Transcriptomes (GIFT) for the simultaneous detection of large numbers of targeted genetic variants with whole transcriptome profiles in single cells....

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Literature Corpus work: c5e2c87e-6741-52da-8018-fdcd243f8af7
DOI: 10.64898/2026.04.11.717967

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