CHIP ahoy: charting a decade of discovery in clonal hematopoiesis.

Abstract excerpt

Clonal hematopoiesis (CH) involves the expansion of hematopoietic stem cells with age-acquired mutations linked to myeloid malignancy. Advances in next-generation and single-cell sequencing, along with computational modeling, have expanded our ability to detect both common and rare CH drivers, including single-nucleotide variants and mosaic chromosomal alterations, with increasing sensitivity. While sequencing...

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