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Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome

2024-06-16

Abstract excerpt

Diploid human cells contain two non-identical genomes, and differences in their regulation underlie human development and disease. We present Fiber-seq Inferred Regulatory Elements (FIRE) and show that FIRE provides a more comprehensive and quantitative snapshot of the accessible chromatin landscape across the 6 Gbp diploid human genome, overcoming previously unrecognized biases in existing regulatory element cata...

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Literature Corpus work
248c7ad1-6e5a-56aa-831e-c9e2d74ec397
DOI
10.1101/2024.06.14.599122
Open publication

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Somatic epimutations cap genetic determinism in the human diploid chromatin epigenomeDOI 10.1101/2024.06.14.599122
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