Mapping genotypes to chromatin accessibility profiles in single cells.

doi:10.1038/s41586-024-07388-y

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Article

Mapping genotypes to chromatin accessibility profiles in single cells.

Nature - 1 May 2024

Izzo Franco, Myers Robert M, Ganesan Saravanan, Mekerishvili Levan, Kottapalli Sanjay, Prieto Tamara, Eton Elliot O, Botella Theo, Dunbar Andrew J, Bowman Robert L, Sotelo Jesus, Potenski Catherine, Mimitou Eleni P, Stahl Maximilian, El Ghaity-Beckley Sebastian, Arandela JoAnn, Raviram Ramya, Choi Daniel C, Hoffman Ronald, Chaligné Ronan, Abdel-Wahab Omar, Smibert Peter, Ghobrial Irene M, Scandura Joseph M, Marcellino Bridget, Levine Ross L, Landau Dan A

Abstract excerpt

In somatic tissue differentiation, chromatin accessibility changes govern priming and precursor commitment towards cellular fates1-3. Therefore, somatic mutations are likely to alter chromatin accessibility patterns, as they disrupt differentiation topologies leading to abnormal clonal outgrowth. However, defining the impact of somatic mutations on the epigenome in human samples is challenging due to admixed...

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PMID: 38720070
DOI: 10.1038/s41586-024-07388-y
PMCID: PMC11139586

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