Article

Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in <i>JAK2</i> -mutant myeloproliferative neoplasms

2020-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Some cancers originate from a single mutation event in a single cell. For example, blood cancers known as myeloproliferative neoplasms (MPN) are thought to originate through the acquisition of a driver mutation (most commonly JAK2 -V617F) in a hematopoietic stem cell (HSC). However, when the mutation first occurs in individual patients and how it impacts the behavior of HSCs in their native con...

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Literature Corpus work: 2cd6b274-94b4-52c8-ad44-bbd4842130f9
DOI: 10.1101/2020.08.24.265058

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