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Article

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.

Nature genetics - 1 Oct 2022

Nam Anna S, Dusaj Neville, Izzo Franco, Murali Rekha, Myers Robert M, Mouhieddine Tarek H, Sotelo Jesus, Benbarche Salima, Waarts Michael, Gaiti Federico, Tahri Sabrin, Levine Ross, Abdel-Wahab Omar, Godley Lucy A, Chaligne Ronan, Ghobrial Irene, Landau Dan A

Abstract excerpt

Somatic mutations in cancer genes have been detected in clonal expansions across healthy human tissue, including in clonal hematopoiesis. However, because mutated and wild-type cells are admixed, we have limited ability to link genotypes with phenotypes. To overcome this limitation, we leveraged multi-modality single-cell sequencing, capturing genotype, transcriptomes and methylomes in progenitors from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36138229
DOI: 10.1038/s41588-022-01179-9
PMCID: PMC10068894

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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.PMID 36138229Read ↗

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