Article

Massively parallel single-cell profiling of transcriptome and multiple epigenetic proteins in cell fate regulation

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Sculpting the epigenome with a combination of histone modifications and transcription factor (TF) occupancy determines gene transcription and cell fate specification. Here we first develop uCoTarget, utilizing a split-pool barcoding strategy for realizing ultra-high throughput single-cell joint profiling of multiple epigenetic proteins. Through extensive optimization for sensitivity and multimod...

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Literature Corpus work: a25029e3-c87b-59c7-9d4a-63b2fb1fbc41
DOI: 10.1101/2023.04.04.535478

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