Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesis

Abstract excerpt

L1 retrotransposition is a significant source of genomic variation in human epithelial tumours, which can contribute to tumorigenesis. However, fundamental questions about the causes and consequences of L1 activity in cancer genomes remain unresolved, primarily due to the limitations of short-read sequencing technologies. Here, we employ multiplatform sequencing, with an emphasis on long reads, to analyse a fine s...

Topics

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• Colorectal Neoplasms
• Genome, Human
• Long Interspersed Nucleotide Elements
• Methylation
• Microsatellite Instability
• Mutagenesis, Insertional
• Reproducibility of Results
• Retroelements

Identifiers and source

Literature Corpus work

479b7044-a878-5f3c-b755-584618d89c53

DOI

10.1101/2024.08.27.596794