Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Landscape of somatic retrotransposition in human cancers.

Science (New York, N.Y.) - 24 Aug 2012

Lee Eunjung, Iskow Rebecca, Yang Lixing, Gokcumen Omer, Haseley Psalm, Luquette Lovelace J, Lohr Jens G, Harris Christopher C, Ding Li, Wilson Richard K, Wheeler David A, Gibbs Richard A, Kucherlapati Raju, Lee Charles, Kharchenko Peter V, Park Peter J

Abstract excerpt

Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleoti...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Neoplasm
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Long Interspersed Nucleotide Elements

Share to Microsatellite Instability

Share to Molecular Sequence Annotation

Share to Multiple Myeloma

Share to Mutagenesis, Insertional

Share to Retroelements

Source

Open in PubMed Open full text

Identifiers

PMID: 22745252
DOI: 10.1126/science.1222077
PMCID: PMC3656569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22745252-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Landscape of somatic retrotransposition in human cancers.PMID 22745252Read ↗

Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genomeSemantic proximity Read ↗

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumoursSemantic proximity Read ↗

Active Human Transposable Elements: Long-Read Sequencing Technologies, Computational Analysis, and Implications for Human DiseaseSemantic proximity Read ↗

Patterns of Transposable Element Expression and Insertion in CancerSemantic proximity Read ↗

Comprehensive identification of transposable element insertions using multiple sequencing technologies.Semantic proximity Read ↗

Extensive mosaicism by somatic L1 retrotransposition in normal human cellsSemantic proximity Read ↗

Characterizing cytosine methylation of polymorphic human transposable element insertions using human pangenome resourcesSemantic proximity Read ↗

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAsSemantic proximity Read ↗

Extensive somatic L1 retrotransposition in colorectal tumors.Semantic proximity Read ↗

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesisSemantic proximity Read ↗

How do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.Semantic proximity Read ↗

Landscape of Large-Scale Somatic Genomic Insertions in Non-Small Cell Lung Carcinoma Revealed by Nanopore SequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.