Article

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

2017-08-24

Abstract excerpt

About half of all cancers have somatic integrations of retrotransposons. To characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 37 histological cancer subtypes. We identified 19,166 somatically acquired retrotransposition events, affecting 35% of samples, and spanning a range of event types. L1 insertions emerged as the first mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42362b0a-6b02-5a76-9c66-5c0addbcf455
DOI: 10.1101/179705

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumoursDOI 10.1101/179705Read

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesisSemantic proximity Read

Landscape of somatic retrotransposition in human cancers.Semantic proximity Read

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangementsSemantic proximity Read

Extensive mosaicism by somatic L1 retrotransposition in normal human cellsSemantic proximity Read

Patterns of somatic genome rearrangement in human cancerSemantic proximity Read

RetroTest unravels LINE-1 retrotransposition in Head and Neck Squamous Cell CarcinomaSemantic proximity Read

Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAsSemantic proximity Read

Immune signatures correlate with L1 retrotransposition in gastrointestinal cancersSemantic proximity Read

Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activitySemantic proximity Read

Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genomeSemantic proximity Read

Extensive somatic L1 retrotransposition in colorectal tumors.Semantic proximity Read

Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomasSemantic proximity Read