Article
Extensive somatic L1 retrotransposition in colorectal tumors.
Genome research - 1 Dec 2012
Solyom Szilvia, Ewing Adam D, Rahrmann Eric P, Doucet Tara, Nelson Heather H, Burns Michael B, Harris Reuben S, Sigmon David F, Casella Alex, Erlanger Bracha, Wheelan Sarah, Upton Kyle R, Shukla Ruchi, Faulkner Geoffrey J, Largaespada David A, Kazazian Haig H
Abstract excerpt
L1 retrotransposons comprise 17% of the human genome and are its only autonomous mobile elements. Although L1-induced insertional mutagenesis causes Mendelian disease, their mutagenic load in cancer has been elusive. Using L1-targeted resequencing of 16 colorectal tumor and matched normal DNAs, we found that certain cancers were excessively mutagenized by human-specific L1s, while no verifiable insertions were...
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