Article

L1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements

2025-09-18

Abstract excerpt

LINE-1 retrotransposition is common in human cancers and rearrangements at insertion sites can contribute to cancer-driving oncogene amplifications and promote genome instability. However, the mechanisms underlying rearrangements of L1 retrotransposition intermediates are poorly understood. To address this gap, we developed GFP-based recombination reporter assays to study the formation of L1 retrotransposition-med...

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Literature Corpus work: 13224a2b-3c1b-5521-8043-234626980c05
DOI: 10.1101/2025.09.17.676864

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