Extensive mosaicism by somatic L1 retrotransposition in normal human cells

Abstract excerpt

<h4>Summary</h4> Over the course of an individual’s lifetime, genomic alterations accumulate in somatic cells. However, the mutational landscape by retrotranspositions of long interspersed nuclear element-1 ( L1 ), a widespread mobile element in the human genome, is poorly understood in normal cells. Here, we explored the whole-genome sequences of 892 single-cell clones established from various tissues collected...

Topics

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• Genes, Neoplasm
• Glioblastoma
• Long Interspersed Nucleotide Elements
• Microsatellite Instability
• Molecular Sequence Annotation
• Multiple Myeloma
• Mutagenesis, Insertional
• Retroelements

Identifiers and source

Literature Corpus work

9277e013-4dd9-5542-9339-a4723365dc7d

DOI

10.1101/2022.05.18.492429