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Structural Variation in Cancer: Role, Prevalence, and Mechanisms.

Annual review of genomics and human genetics - 31 Aug 2022

Cosenza Marco Raffaele, Rodriguez-Martin Bernardo, Korbel Jan O

Abstract excerpt

Somatic rearrangements resulting in genomic structural variation drive malignant phenotypes by altering the expression or function of cancer genes. Pan-cancer studies have revealed that structural variants (SVs) are the predominant class of driver mutation in most cancer types, but because they are difficult to discover, they remain understudied when compared with point mutations. This review provides an overview...

Topics

Genome, Human
Genomic Structural Variation
Genomics
Humans
Mutation
Neoplasms
Prevalence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35655332
DOI: 10.1146/annurev-genom-120121-101149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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