Article

Comprehensive locus-specific L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites

2023-01-03

Abstract excerpt

<h4>SUMMARY</h4> Long interspersed element-1 (L1) retrotransposons play important roles in human disease and evolution. Their global activity is repressed by DNA methylation, but studying the regulation of individual copies has been difficult. Here, we combine short- and long-read sequencing to resolve the DNA methylation profiles of these repeated sequences in a panel of normal and cancer cells genome-wide at si...

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Literature Corpus work: ffe031a4-49c0-527e-819e-2f9a3ff96095
DOI: 10.1101/2023.01.03.522582

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