Article

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription

2023-05-12

Abstract excerpt

Somatic activity of LINE-1 (L1) mobile elements has been implicated in cancer etiology, which may be related to the loss of p53-mediated regulation as a result of TP53 mutations. Quantifying the mechanisms of L1 regulation in cancer has been challenging. Here, we build a statistical model of L1 regulation by simultaneously quantifying L1 retrotransposition, L1 expression, and the fitness costs of mutated TP53 wi...

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Literature Corpus work: 6b40d104-3950-5f0c-ac53-b9893c6ed58c
DOI: 10.1101/2023.05.11.539471

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