Article

Selective and mechanistic sources of recurrent rearrangements across the cancer genome

2017-09-14

Abstract excerpt

Cancer cells can acquire profound alterations to the structure of their genomes, including rearrangements that fuse distant DNA breakpoints. We analyze the distribution of somatic rearrangements across the cancer genome, using whole-genome sequencing data from 2,693 tumor-normal pairs. We observe substantial variation in the density of rearrangement breakpoints, with enrichment in open chromatin and sites with hig...

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Literature Corpus work: 128b6e83-4311-54de-bfab-8deaa6607dfe
DOI: 10.1101/187609

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