Article

Patterns of somatic genome rearrangement in human cancer

2018-01-01

Abstract excerpt

Cancer development is driven by somatic genome alterations, ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, and a lack of methods for comprehensive structural classification and downstream analysis. The ICGC project on the Pa...

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Literature Corpus work: 7efb55f9-da1e-5c91-a192-2e45b3342d04
DOI: 10.17863/cam.22674

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