L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution.

doi:10.1016/j.celrep.2018.05.090

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution.

Cell reports - 26 Jun 2018

Nguyen Thu H M, Carreira Patricia E, Sanchez-Luque Francisco J, Schauer Stephanie N, Fagg Allister C, Richardson Sandra R, Davies Claire M, Jesuadian J Samuel, Kempen Marie-Jeanne H C, Troskie Robin-Lee, James Cini, Beaven Elizabeth A, Wallis Tristan P, Coward Jermaine I G, Chetty Naven P, Crandon Alexander J, Venter Deon J, Armes Jane E, Perrin Lewis C, Hooper John D, Ewing Adam D, Upton Kyle R, Faulkner Geoffrey J

Abstract excerpt

LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis remains unclear. Here, we applied retrotransposon capture sequencing (RC-seq) to multiple single-cell clones isolated from five ovarian cancer cell lines and HeLa cells and detected endogenous L1 retrotransposition in vitro. We then applied RC-seq to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Drug Resistance, Neoplasm

Share to Glycoproteins

Share to Long Interspersed Nucleotide Elements

Share to Loss of Heterozygosity

Share to Mutagenesis, Insertional

Share to Ovarian Neoplasms

Source

Open in PubMed

Identifiers

PMID: 29949758
DOI: 10.1016/j.celrep.2018.05.090

Genes

STC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution.PMID 29949758Read ↗

L1 retrotransposition is regulated post-transcriptionally In High-Grade Serous Ovarian CancerSemantic proximity Read ↗

Extensive mosaicism by somatic L1 retrotransposition in normal human cellsSemantic proximity Read ↗

Synchronous L1 retrotransposition events promote chromosomal crossover early in human tumorigenesisSemantic proximity Read ↗

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumoursSemantic proximity Read ↗

Extensive somatic L1 retrotransposition in colorectal tumors.Semantic proximity Read ↗

LINE-1 retrotransposon-mediated DNA transductions in endometriosis associated ovarian cancers.Semantic proximity Read ↗

LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-SeqSemantic proximity Read ↗

LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5’ single-cell RNA-SeqSemantic proximity Read ↗

Landscape of somatic retrotransposition in human cancers.Semantic proximity Read ↗

RetroTest unravels LINE-1 retrotransposition in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing.Semantic proximity Read ↗

A comprehensive identification and annotation of mobile LINE-1 retrotransposons across human reference and personal genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.